Cathedral concept synthesis
Question lineage
Historical attribution is preserved; a verified contributor profile can be linked when primary evidence supports it.
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Retrieving and screening evidence
Ghost node / Structural gap
Artemisinin requires activation by heme to become toxic to the parasite. K13 mutations appear to reduce activation, but the complete pathway connecting K13 function to heme release remains disputed.
Resolution contract
A mechanism connecting K13 perturbation to altered parasite clearance that survives independent experimental challenge.
Lineage
Evidence record
No evidence has been attached. Start an investigation or attach the first traceable source.
Investigations
No investigation has started. The first researcher becomes the node steward.
Independent review
No published reviews. A node cannot be resolved without at least one independent supporting review.
Contributor credit
Cathedral concept synthesis
Question lineage
Historical attribution is preserved; a verified contributor profile can be linked when primary evidence supports it.
Progress ledger