Cathedral concept synthesis
Question lineage
Historical attribution is preserved; a verified contributor profile can be linked when primary evidence supports it.
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Retrieving and screening evidence
Ghost node / Structural gap
The C580Y mutation accounts for the majority of validated artemisinin resistance cases globally. Other K13 mutations also confer resistance but are less prevalent; the structural and biochemical reason C580Y is so successful remains unresolved.
Resolution contract
A validated structural or biochemical comparison that explains the relative selection advantage of major K13 variants.
Lineage
Evidence record
No evidence has been attached. Start an investigation or attach the first traceable source.
Investigations
No investigation has started. The first researcher becomes the node steward.
Independent review
No published reviews. A node cannot be resolved without at least one independent supporting review.
Contributor credit
Cathedral concept synthesis
Question lineage
Historical attribution is preserved; a verified contributor profile can be linked when primary evidence supports it.
Progress ledger