Open questions
A ghost node is a testable unknown with lineage, a resolution contract, evidence, active investigations, independent review, and contributor credit.
Open
58
Ready for investigation
Investigating
1
Workspaces in progress
Resolution record
0
Under review or resolved
Canonical registry
These records are durable. Their state can change only through evidence, completed investigation, and review.
USGS, Understanding plate motions
Answered when: A steward must define the evidence required for resolution.
Continental drift and plate tectonics
2026 / 0 active researchers
Open for a bounded, evidence-backed investigation.
Reviewed Sep 8, 2026
Open research recordNCI RAS Initiative
Type B gap audit
Cathedral inspects definitions, scales, boundary conditions, shared assumptions, and missing discriminating measurements. Outputs remain candidates until a person validates and promotes them.
No private gap candidates yet. Run an audit or generate a decomposition from a research workspace.
Answered when: A steward must define the evidence required for resolution.
KRAS as a therapeutic target
2026 / 0 active researchers
Open for a bounded, evidence-backed investigation.
Reviewed Sep 8, 2026
Open research recordFOXP3 and regulatory T cell biology
Answered when: A steward must define the evidence required for resolution.
FOXP3 and regulatory T-cell biology
2026 / 0 active researchers
Open for a bounded, evidence-backed investigation.
Reviewed Sep 8, 2026
Open research recordAmerican College of Gastroenterology guideline on H. pylori treatment
Answered when: A steward must define the evidence required for resolution.
Helicobacter pylori and peptic ulcer disease
2026 / 0 active researchers
Open for a bounded, evidence-backed investigation.
Reviewed Sep 8, 2026
Open research recordSub-optimal dosing and incomplete treatment courses may drive resistance. It remains open whether dispensing patterns can predict future hotspots before clinical failure is observed.
Answered when: A prospectively validated model showing that treatment-pattern signals improve hotspot prediction beyond genomic and clinical surveillance alone.
Artemisinin Resistance
2026 / 1 active researchers
Active work is attached.
Reviewed Aug 13, 2026
Open research recordArtemisinin requires activation by heme to become toxic to the parasite. K13 mutations appear to reduce activation, but the complete pathway connecting K13 function to heme release remains disputed.
Answered when: A mechanism connecting K13 perturbation to altered parasite clearance that survives independent experimental challenge.
Artemisinin Resistance
2026 / 0 active researchers
Open for a bounded, evidence-backed investigation.
Reviewed Aug 13, 2026
Open research recordIf K13 mutations carry high fitness cost, resistance may recede without sustained drug pressure. If low cost, it may persist; current data is contradictory across studies.
Answered when: Comparable competition experiments across key East African variants, with and without drug pressure, reproduced by an independent group.
Artemisinin Resistance
2026 / 0 active researchers
Open for a bounded, evidence-backed investigation.
Reviewed Aug 13, 2026
Open research recordThe C580Y mutation accounts for the majority of validated artemisinin resistance cases globally. Other K13 mutations also confer resistance but are less prevalent; the structural and biochemical reason C580Y is so successful remains unresolved.
Answered when: A validated structural or biochemical comparison that explains the relative selection advantage of major K13 variants.
Artemisinin Resistance
2026 / 0 active researchers
Open for a bounded, evidence-backed investigation.
Reviewed Aug 13, 2026
Open research recordUganda has high confirmed K13 mutation prevalence despite Tanzania having comparable ACT usage and similar regional conditions. The epidemiological and genomic asymmetry is not fully explained.
Answered when: A cross-border model that distinguishes surveillance intensity, lineage movement, treatment pressure, and parasite fitness with out-of-sample validation.
Artemisinin Resistance
2026 / 0 active researchers
Open for a bounded, evidence-backed investigation.
Reviewed Aug 13, 2026
Open research recordExisting drug combinations might overcome K13-mediated resistance faster than new drug development. Comprehensive computational screening remains incomplete.
Answered when: A reproducible comparison showing that an existing regimen suppresses resistant lineages without unacceptable loss of efficacy or safety.
Artemisinin Resistance
2026 / 0 active researchers
Open for a bounded, evidence-backed investigation.
Reviewed Aug 13, 2026
Open research recordSome treatment failure cases show no K13 mutation, suggesting alternative resistance mechanisms may exist but are not yet characterized.
Answered when: Replicated clinical or laboratory evidence for a resistance phenotype after established K13 and partner-drug explanations are excluded.
Artemisinin Resistance
2026 / 0 active researchers
Open for a bounded, evidence-backed investigation.
Reviewed Aug 13, 2026
Open research recordThe tension between semiclassical evaporation and unitary quantum evolution remains unresolved at the level of a complete, experimentally grounded theory.
Answered when: A steward must define the evidence required for resolution.
Hawking Radiation
1976 / 0 active researchers
Open for a bounded, evidence-backed investigation.
Reviewed Jul 13, 2026
Open research recordPerformance has advanced faster than dependable mechanistic interpretation.
Answered when: A steward must define the evidence required for resolution.
Machine Learning
1959 / 0 active researchers
Open for a bounded, evidence-backed investigation.
Reviewed Jul 13, 2026
Open research recordModern systems amplify the original learning-machine question: when does learned behavior remain dependable in unfamiliar conditions?
Answered when: A steward must define the evidence required for resolution.
Machine Learning
1950 / 0 active researchers
New evidence invalidated or qualified the former resolution.
Reviewed Jul 13, 2026
Open research recordSequence context, cell state, repair pathway, and measurement sensitivity still limit universal prediction.
Answered when: A steward must define the evidence required for resolution.
CRISPR-Cas9
2012 / 0 active researchers
Open for a bounded, evidence-backed investigation.
Reviewed Jul 13, 2026
Open research recordDelivery, immune response, tissue specificity, and manufacturability remain coupled bottlenecks.
Answered when: A steward must define the evidence required for resolution.
CRISPR-Cas9
2012 / 0 active researchers
Open for a bounded, evidence-backed investigation.
Reviewed Jul 13, 2026
Open research recordNo agreed bridge principle connects objective mechanism to phenomenal experience.
Answered when: A steward must define the evidence required for resolution.
The Hard Problem of Consciousness
1995 / 0 active researchers
Open for a bounded, evidence-backed investigation.
Reviewed Jul 13, 2026
Open research recordThreshold theorems establish possibility, but system-level overhead and correlated noise remain decisive.
Answered when: A steward must define the evidence required for resolution.
Quantum Error Correction
1995 / 0 active researchers
Open for a bounded, evidence-backed investigation.
Reviewed Jul 13, 2026
Open research recordRelativistic effects and short lifetimes make the chemistry of the heaviest elements difficult to establish.
Answered when: A steward must define the evidence required for resolution.
Periodic System
1960 / 0 active researchers
Open for a bounded, evidence-backed investigation.
Reviewed Jul 13, 2026
Open research recordThis structural gap was preserved from the concept's unresolved-question record.
Answered when: A source-linked result must answer the question under explicit assumptions and survive independent review.
Dark Matter
2026 / 1 active researchers
Open for a bounded, evidence-backed investigation.
Reviewed Jul 31, 2026
Open research recordThis structural gap was preserved from the concept's unresolved-question record.
Answered when: A source-linked result must answer the question under explicit assumptions and survive independent review.
Dark Matter
2026 / 1 active researchers
Open for a bounded, evidence-backed investigation.
Reviewed Jul 31, 2026
Open research recordThis structural gap was preserved from the concept's unresolved-question record.
Answered when: A source-linked result must answer the question under explicit assumptions and survive independent review.
Dark Matter
2026 / 1 active researchers
Open for a bounded, evidence-backed investigation.
Reviewed Jul 31, 2026
Open research recordThis structural gap was preserved from the concept's unresolved-question record.
Answered when: A source-linked result must answer the question under explicit assumptions and survive independent review.
Consciousness
2026 / 1 active researchers
Open for a bounded, evidence-backed investigation.
Reviewed Jul 31, 2026
Open research recordThis structural gap was preserved from the concept's unresolved-question record.
Answered when: A source-linked result must answer the question under explicit assumptions and survive independent review.
Consciousness
2026 / 1 active researchers
Open for a bounded, evidence-backed investigation.
Reviewed Jul 31, 2026
Open research recordThis structural gap was preserved from the concept's unresolved-question record.
Answered when: A source-linked result must answer the question under explicit assumptions and survive independent review.
Consciousness
2026 / 1 active researchers
Open for a bounded, evidence-backed investigation.
Reviewed Jul 31, 2026
Open research recordThis structural gap was preserved from the concept's unresolved-question record.
Answered when: A source-linked result must answer the question under explicit assumptions and survive independent review.
Consciousness
2026 / 1 active researchers
Open for a bounded, evidence-backed investigation.
Reviewed Jul 31, 2026
Open research recordThis structural gap was preserved from the concept's unresolved-question record.
Answered when: A source-linked result must answer the question under explicit assumptions and survive independent review.
Consciousness
2026 / 1 active researchers
Open for a bounded, evidence-backed investigation.
Reviewed Jul 31, 2026
Open research recordThis structural gap was preserved from the concept's unresolved-question record.
Answered when: A source-linked result must answer the question under explicit assumptions and survive independent review.
Lung Cancer
2026 / 1 active researchers
Open for a bounded, evidence-backed investigation.
Reviewed Jul 31, 2026
Open research recordThis structural gap was preserved from the concept's unresolved-question record.
Answered when: A source-linked result must answer the question under explicit assumptions and survive independent review.
Lung Cancer
2026 / 1 active researchers
Open for a bounded, evidence-backed investigation.
Reviewed Jul 31, 2026
Open research recordThis structural gap was preserved from the concept's unresolved-question record.
Answered when: A source-linked result must answer the question under explicit assumptions and survive independent review.
Lung Cancer
2026 / 1 active researchers
Open for a bounded, evidence-backed investigation.
Reviewed Jul 31, 2026
Open research recordThis structural gap was preserved from the concept's unresolved-question record.
Answered when: A source-linked result must answer the question under explicit assumptions and survive independent review.
Lung Cancer
2026 / 1 active researchers
Open for a bounded, evidence-backed investigation.
Reviewed Jul 31, 2026
Open research recordThis structural gap was preserved from the concept's unresolved-question record.
Answered when: A source-linked result must answer the question under explicit assumptions and survive independent review.
Https://www.instagram.com/reel/dyr4ppyvnfd/?igsh=mtfqb2h5chvod2jxdq==
2026 / 1 active researchers
Open for a bounded, evidence-backed investigation.
Reviewed Jul 31, 2026
Open research recordThis structural gap was preserved from the concept's unresolved-question record.
Answered when: A source-linked result must answer the question under explicit assumptions and survive independent review.
Https://www.instagram.com/reel/dyr4ppyvnfd/?igsh=mtfqb2h5chvod2jxdq==
2026 / 1 active researchers
Open for a bounded, evidence-backed investigation.
Reviewed Jul 31, 2026
Open research recordThis structural gap was preserved from the concept's unresolved-question record.
Answered when: A source-linked result must answer the question under explicit assumptions and survive independent review.
Https://www.instagram.com/reel/dyr4ppyvnfd/?igsh=mtfqb2h5chvod2jxdq==
2026 / 1 active researchers
Open for a bounded, evidence-backed investigation.
Reviewed Jul 31, 2026
Open research recordThis structural gap was preserved from the concept's unresolved-question record.
Answered when: A source-linked result must answer the question under explicit assumptions and survive independent review.
From Bench To Bedside: Future Prospects In Stem Cell Therapy For Diabetes
2026 / 1 active researchers
Open for a bounded, evidence-backed investigation.
Reviewed Jul 31, 2026
Open research recordThis structural gap was preserved from the concept's unresolved-question record.
Answered when: A source-linked result must answer the question under explicit assumptions and survive independent review.
From Bench To Bedside: Future Prospects In Stem Cell Therapy For Diabetes
2026 / 1 active researchers
Open for a bounded, evidence-backed investigation.
Reviewed Jul 31, 2026
Open research recordThis structural gap was preserved from the concept's unresolved-question record.
Answered when: A source-linked result must answer the question under explicit assumptions and survive independent review.
From Bench To Bedside: Future Prospects In Stem Cell Therapy For Diabetes
2026 / 1 active researchers
Open for a bounded, evidence-backed investigation.
Reviewed Jul 31, 2026
Open research recordThis structural gap was preserved from the concept's unresolved-question record.
Answered when: A source-linked result must answer the question under explicit assumptions and survive independent review.
Https://www.youtube.com/shorts/ou0z8_ufyni
2026 / 1 active researchers
Open for a bounded, evidence-backed investigation.
Reviewed Jul 31, 2026
Open research recordThe reason this question remains open has not been recorded yet.
Answered when: A steward must define the evidence required for resolution.
Fusion Plasma Exhaust
2026 / 0 active researchers
Open for a bounded, evidence-backed investigation.
Reviewed Jul 31, 2026
Open research recordThis structural gap was preserved from the concept's unresolved-question record.
Answered when: A source-linked result must answer the question under explicit assumptions and survive independent review.
Https://www.youtube.com/shorts/ou0z8_ufyni
2026 / 1 active researchers
Open for a bounded, evidence-backed investigation.
Reviewed Jul 31, 2026
Open research recordThis structural gap was preserved from the concept's unresolved-question record.
Answered when: A source-linked result must answer the question under explicit assumptions and survive independent review.
Sleep
2026 / 1 active researchers
Open for a bounded, evidence-backed investigation.
Reviewed Jul 31, 2026
Open research recordThis structural gap was preserved from the concept's unresolved-question record.
Answered when: A source-linked result must answer the question under explicit assumptions and survive independent review.
Sleep
2026 / 1 active researchers
Open for a bounded, evidence-backed investigation.
Reviewed Jul 31, 2026
Open research recordThis structural gap was preserved from the concept's unresolved-question record.
Answered when: A source-linked result must answer the question under explicit assumptions and survive independent review.
Sleep
2026 / 1 active researchers
Open for a bounded, evidence-backed investigation.
Reviewed Jul 31, 2026
Open research recordThis structural gap was preserved from the concept's unresolved-question record.
Answered when: A source-linked result must answer the question under explicit assumptions and survive independent review.
Was The Big Bang Really The Start? What Other Scenarios Are Their?
2026 / 1 active researchers
Open for a bounded, evidence-backed investigation.
Reviewed Jul 31, 2026
Open research recordThis structural gap was preserved from the concept's unresolved-question record.
Answered when: A source-linked result must answer the question under explicit assumptions and survive independent review.
Was The Big Bang Really The Start? What Other Scenarios Are Their?
2026 / 1 active researchers
Open for a bounded, evidence-backed investigation.
Reviewed Jul 31, 2026
Open research recordThis structural gap was preserved from the concept's unresolved-question record.
Answered when: A source-linked result must answer the question under explicit assumptions and survive independent review.
Was The Big Bang Really The Start? What Other Scenarios Are Their?
2026 / 1 active researchers
Open for a bounded, evidence-backed investigation.
Reviewed Jul 31, 2026
Open research recordThis structural gap was preserved from the concept's unresolved-question record.
Answered when: A source-linked result must answer the question under explicit assumptions and survive independent review.
Fasting
2026 / 1 active researchers
Open for a bounded, evidence-backed investigation.
Reviewed Jul 31, 2026
Open research recordThis structural gap was preserved from the concept's unresolved-question record.
Answered when: A source-linked result must answer the question under explicit assumptions and survive independent review.
Fasting
2026 / 1 active researchers
Open for a bounded, evidence-backed investigation.
Reviewed Jul 31, 2026
Open research recordThis structural gap was preserved from the concept's unresolved-question record.
Answered when: A source-linked result must answer the question under explicit assumptions and survive independent review.
Fasting
2026 / 1 active researchers
Open for a bounded, evidence-backed investigation.
Reviewed Jul 31, 2026
Open research recordThis structural gap was preserved from the concept's unresolved-question record.
Answered when: A source-linked result must answer the question under explicit assumptions and survive independent review.
Artemisinin Resistance
2026 / 0 active researchers
Open for a bounded, evidence-backed investigation.
Reviewed Jul 31, 2026
Open research recordThis structural gap was preserved from the concept's unresolved-question record.
Answered when: A source-linked result must answer the question under explicit assumptions and survive independent review.
Artemisinin Resistance
2026 / 0 active researchers
Open for a bounded, evidence-backed investigation.
Reviewed Jul 31, 2026
Open research recordThis structural gap was preserved from the concept's unresolved-question record.
Answered when: A source-linked result must answer the question under explicit assumptions and survive independent review.
Artemisinin Resistance
2026 / 0 active researchers
Open for a bounded, evidence-backed investigation.
Reviewed Jul 31, 2026
Open research recordThis structural gap was preserved from the concept's unresolved-question record.
Answered when: A source-linked result must answer the question under explicit assumptions and survive independent review.
Https://www.youtube.com/shorts/ou0z8_ufyni
2026 / 1 active researchers
Open for a bounded, evidence-backed investigation.
Reviewed Jul 31, 2026
Open research recordThe reason this question remains open has not been recorded yet.
Answered when: A steward must define the evidence required for resolution.
Fusion Plasma Exhaust
2026 / 0 active researchers
Open for a bounded, evidence-backed investigation.
Reviewed Jul 31, 2026
Open research recordThe reason this question remains open has not been recorded yet.
Answered when: A steward must define the evidence required for resolution.
Fusion Plasma Exhaust
2026 / 0 active researchers
Open for a bounded, evidence-backed investigation.
Reviewed Jul 31, 2026
Open research recordThe reason this question remains open has not been recorded yet.
Answered when: A steward must define the evidence required for resolution.
Pancreatic Cancer Early Detection
2026 / 0 active researchers
Open for a bounded, evidence-backed investigation.
Reviewed Jul 31, 2026
Open research recordThe reason this question remains open has not been recorded yet.
Answered when: A steward must define the evidence required for resolution.
Pancreatic Cancer Early Detection
2026 / 0 active researchers
Open for a bounded, evidence-backed investigation.
Reviewed Jul 31, 2026
Open research recordThe reason this question remains open has not been recorded yet.
Answered when: A steward must define the evidence required for resolution.
Pancreatic Cancer Early Detection
2026 / 0 active researchers
Open for a bounded, evidence-backed investigation.
Reviewed Jul 31, 2026
Open research recordThe reason this question remains open has not been recorded yet.
Answered when: A steward must define the evidence required for resolution.
UAP Evidence Standards
2023 / 0 active researchers
Open for a bounded, evidence-backed investigation.
Reviewed Jul 31, 2026
Open research recordThe reason this question remains open has not been recorded yet.
Answered when: A steward must define the evidence required for resolution.
UAP Evidence Standards
2023 / 0 active researchers
Open for a bounded, evidence-backed investigation.
Reviewed Jul 31, 2026
Open research recordThe reason this question remains open has not been recorded yet.
Answered when: A steward must define the evidence required for resolution.
UAP Evidence Standards
2023 / 0 active researchers
Open for a bounded, evidence-backed investigation.
Reviewed Jul 31, 2026
Open research recordCompeting theories often accommodate overlapping experimental results.
Answered when: A steward must define the evidence required for resolution.
The Hard Problem of Consciousness
1995 / 0 active researchers
Open for a bounded, evidence-backed investigation.
Reviewed Jul 13, 2026
Open research recordAnalogue systems test aspects of the kinematics, but direct astrophysical discrimination remains open.
Answered when: A steward must define the evidence required for resolution.
Hawking Radiation
1975 / 0 active researchers
Open for a bounded, evidence-backed investigation.
Reviewed Jul 13, 2026
Open research record